Rohit Arora

Research Fellow

Beth Israel Deaconess Medical Center, Harvard Medical School

(Boston MA, USA)

​2015 - Present

• Computational investigation of the complexities of the immune system at protein sequence and structural level, by developing mathematical data models from patient data, and analyzing three-dimensional structural models 

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Post-doctoral Researcher

ICOA, Université d'Orléans (Orléans, France)

​2012 - 2014

• As a part of the consortium led by Janssen Pharmaceutica (Beerse, Belgium), investigated the structural flexibility and conformational patterns of several Cancer causing Kinase proteins and their inhibitors, using computational methods

• Gained experience in Machine Learning and Data Mining techniques (KNIME) and used it to analyse complex biological and structural simulation data

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Doctoral Student

Ecole Normale Supérieure (Cachan, France)

​2009 - 2012

• Explored the inhibition mechanism of HIV-1 integrase (a key component in HIV replication), its resistance to inhibitors and its recognition with the viral HIV DNA. Used in-silico methods

• Proposed novel mechanism of recognition between viral HIV DNA and the inhibitor, Raltegravir. This work resulted in 4 publications in peer-reviewed journals

Note: More details on my Postdoctoral and PhD work can be found on the Projects page

Master thesis

Ecole Normale Supérieure (Cachan, France)

​2012 - present

• Performed detailed fragment based and statistical analysis on the binding and recognition HIV-1 integrase and its inhibitors. Project led by Dr. Luba Tchertanov.

Summer Intern

Jawaharlal Nehru University (New Delhi, India)

2008 

• Used simple simulation techniques to study the proton pathway in an AcrB type efflux pumps, which are transport proteins involved in the extrusion of toxic substrates. Project led by Dr. Indira Ghosh.